PHILADELPHIA (AP) -- It was hard to tell whether or not La Salle had won or lost by the contrite, sullen expression Explorers coach John Giannini wore. Giannini was plagued by a 3-point basket one of his final subs sank in the closing seconds of a blowout win Wednesday that brought tension to the postgame handshake line.
At the end of the day, coaches are gentlemen, and the trey didn't sit well with La Salle's bench boss.
Otherwise, Giannini, and La Salle, had plenty to be pleased with, after Tyreek Duren's career-high 29 points led the Explorers to an 82-57 victory in front of 4,382 fans on a late night on Penn University's campus.
The win was La Salle's fourth straight and its first over a Big Ten opponent since 2000.
"I apologize for the last shot," said Giannini, who stomped his foot after O.J. Lewis dropped the final points. "He's a walk-on and he just got excited. It was the first time he'd been on the court."
Penn State coach Patrick Chambers had an emotional second half, including a technical foul, so, the final shot didn't make for a pleasant postgame, midcourt handshake. Later, after the press conferences and after another hallway handshake between the two coaches, the leader of the Nittany Lions had moved on.
"That stuff," he said, quietly, "happens."
The win gave La Salle (5-1) its best start since 2005-06, when the Explorers began 7-0. The Explorers last upended a Big Ten team almost 12 years to the day -- a 62-44 victory over Northwestern on Dec. 10, 2000.
"We made shots and you always look better when you make shots," Giannini said. "Our guards were terrific. But I expect our guards to be terrific. Tyreek is one of the best guards in America. We fought hard, and we battled, and in the end, it was our defense that gave us a chance."
Penn State (4-4) was led by Jermaine Marshall's 19 points, and Ross Travis and D.J. Newbill chipped in with 12 each.
"There's gonna be nights like this," Chambers said. "We don't have a deep bench right now. But we will learn from this."
There were six lead changes in the first 4 minutes before the Explorers took control of the game with a 10-0 tear that snapped a 23-23 tie. From there, La Salle never trailed, though Penn State did close to within a basket twice -- the last at 43-41 after a 3-point play from Newbill with 15:33 left.
Duren, a 6-foot junior guard, opened a close game up by scoring 12 straight points during a 3-minute stretch in the second half. He was supported by 14 points each from Ramon Galloway and Sam Mills.
Duren sank two free throws after Chambers was hit with a technical foul with 7:56 left. By then, La Salle had opened a 65-46 edge.
"It felt like all of my shots were falling, and Coach G just kept on saying 'It's on you tonight'," Duren said. "That felt good. Coach G talked about it all week that this could be a historic game in a historic place."
La Salle was 16 for 31 from beyond the arc, while Penn State shot 33-percent (9 of 27) from the floor in the second and made just 3 of 12 from 3-point range.
"At some point, you just thought they'd stop making 3s," Chambers said of La Salle. "And they didn't. Give them credit."
La Salle -- hosting a rare game off campus -- took a 38-34 halftime lead after holding two different 10-point advantages, at 33-23 and 36-26.